ChloroquineV1, France, Analysis, bibRecord, 000257

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

Identifieur interne : 000257 ( France/Analysis ); précédent : 000256; suivant : 000258

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

Auteurs : Guillaume Marti [France] ; Véronique Eparvier ; Marc Litaudon ; Philippe Grellier ; Françoise Guéritte

Source :

Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2010.

RBID : pubmed:20948498

Descripteurs français

KwdFr :
- Animaux, Antipaludiques (), Antipaludiques (pharmacologie), Clusiaceae (), Extraits de plantes (), Extraits de plantes (pharmacologie), Humains, Plasmodium falciparum (), Structure moléculaire, Xanthones (), Xanthones (pharmacologie), Écorce ().
MESH :
- pharmacologie : Antipaludiques, Extraits de plantes, Xanthones.
- Animaux, Antipaludiques, Clusiaceae, Extraits de plantes, Humains, Plasmodium falciparum, Structure moléculaire, Xanthones, Écorce.

English descriptors

KwdEn :
- Animals, Antimalarials (chemistry), Antimalarials (pharmacology), Clusiaceae (chemistry), Humans, Molecular Structure, Plant Bark (chemistry), Plant Extracts (chemistry), Plant Extracts (pharmacology), Plasmodium falciparum (drug effects), Xanthones (chemistry), Xanthones (pharmacology).
MESH :
- chemical , chemistry : Antimalarials, Plant Extracts, Xanthones.
- chemical , pharmacology : Antimalarials, Plant Extracts, Xanthones.
- chemistry : Clusiaceae, Plant Bark.
- drug effects : Plasmodium falciparum.
- Animals, Humans, Molecular Structure.
mix :
- Clusiaceae, Rheedia acuminata, antiplasmodial activity, cytotoxicity, xanthones.

Abstract

Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone, together with four known compounds. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.

Url:

DOI: 10.3390/molecules15107106
PubMed: 20948498

Affiliations:

Links to Exploration step

pubmed:20948498

Le document en format XML

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<front><div type="abstract" xml:lang="en">Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone, together with four known compounds. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.</div>
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A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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